OKVA Announces Collaboration with Nano Precision Medical, Inc. on Long-Term Drug Delivery System to Develop Novel Therapeutics for Animal Health

Collaboration Leverages NanoPortal™, A Best-in-Class Drug-Device Technology Developed by Nano Precision Medical, For Use in Feline Obesity and Diabetes

San Francisco, California. – October 19, 2019 – OKAVA Pharmaceuticals, Inc., a clinical stage research and development company focused on diseases of aging in dogs and cats, announced today entering into a strategic partnership with Nano Prescison Medical, Inc. (NPM). This collaboration if focused on the development of miniaturized, long-term biopharmaceutical implants for feline obesity and diabetes with the goal of guaranteeing adherence, and potentially to improve tolerance to this medication. The proprietary, novel drug-device combination product (OKV-119) utilizes industry-leading drug delivery technology, NanoPortal™, to develop months long drug release of the GLP-1 exenatide for veterinary use.

“An alarming percentage of pet owners are unable to medicate their dogs and cats because of the challenges associated with drug administration. By leveraging NPM’s NanoPortal technology, we can overcome the challenges of medication non-adherence,” said Michael Klotsman, PhD, chief executive of OKAVA. “By adopting state-of-the-art human technologies, our goal is to bring next generation veterinary therapeutics, with superior product profiles at affordable prices, to the market in order to address unmet medical needs of household pets.”

About OKV-119

OKV-119 is a miniature, subdermal, exenatide drug implant designed to treat the growing number of clinically obese cats and feline diabetes. This device can be conveniently inserted under the skin during routine veterinary visits and is designed to provide steady doses of medication for up to six months.

About OKAVA Pharmaceuticals, Inc.

OKAVA is a clinical-stage research and development company that develops new treatment options for dogs and cats suffering from chronic diseases of aging. OKAVA is building a portfolio of products to transform and humanize standards of care in veterinary medicine. By harnessing human technologies for the treatment of common diseases in household pets, the company has the potential of increasing the lifespans of dogs and cats by an average of 1 to 3 years. OKAVA is a private company headquartered in San Francisco, California. For more information, see OKAVApharma.com.

About NanoPrecision Medical, Inc.

Leveraging its proprietary NanoPortal™ platform, NanoPrecision Medical develops biopharmaceutical implants designed to deliver drug molecules steadily over extended periods of time with the goal of guaranteeing adherence, and potentially to improve tolerance to their medication. NPM’s lead program NPM-119 is a miniaturized, 6-month GLP-1 implant under investigation for the treatment of patients with type 2 diabetes and is also under consideration for the treatment of obesity. NPM-119 is designed to provide patients with the opportunity to realize the full potential benefit of their medication by avoiding the challenges associated with the daily or weekly administration of orals and injectables. Medication non-adherence occurs when patients do not take their medication as prescribed. This affects an alarming number of patients, approximately 50%, including those taking daily pills. Medication non-adherence, which contributes to more than $500 billion in annual avoidable healthcare costs and 125,000 potentially preventable deaths annually in the U.S. alone, is a primary and daunting reason why type 2 diabetes treatments face significant challenges in achieving positive real-world effectiveness.

For More Information:
Michael Klotsman, PhD, MBA Chief Executive Officer at OKAVA
Phone: 415.818.1808
E-mail: info@okavapharma.com

NPM Contact:
Donald Dwyer
Chief Business Officer
info@vivani.com
(415) 506-8462

NPM Investor Relations Contact:
Brigid A. Makes
Chief Financial Officer
investors@vivani.com
(415) 506-8462